Basic Fibroblast Growth Factor Counteracts the Suppressive Effect of Transforming Growth Factor-pl on Human Myeloid Progenitor Cells
نویسندگان
چکیده
We have previously shown that basic fibroblast growth factor (bFGF) is mitogenic for human bone marrow stromal cells and enhances myelopoiesis in human long-term bone marrow culture. In the present study, we examined the mechanism by which bFGF enhances granulopoiesis. We observed that bFGF significantly abrogated the inhibitory effect of transforming growth factor-j3l (TGF-PI) on granulocyte-macrophage colony-stimulating factor (GM-CSF)supported progenitor cell growth (P = .009). The partial reversal of TGF-j31 -mediated suppression was dependent
منابع مشابه
Basic fibroblast growth factor counteracts the suppressive effect of transforming growth factor-beta 1 on human myeloid progenitor cells.
We have previously shown that basic fibroblast growth factor (bFGF) is mitogenic for human bone marrow stromal cells and enhances myelopoiesis in human long-term bone marrow culture. In the present study, we examined the mechanism by which bFGF enhances granulopoiesis. We observed that bFGF significantly abrogated the inhibitory effect of transforming growth factor-beta 1 (TGF-beta 1) on granul...
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